SPECIFICITY OF THE REACTION BETWEEN RHEUMATOID FACTORS AND GAMMA GLOBULIN

Specificity of the Reaction between Rheumatoid Factors and Gamma Globulin

Rheumatoid factors in the sera of patients with rheumatoid arthritis appear to be specifically directed against genetically determined "antigens" in human gamma-globulin. At least eight rheumatoid factors of differing specificity exist; usually several are present in combination in the same serum. The different rheumatoid factors can be readily detected through their pattern of reactivity with ...

Effect of dextran on the reaction between rheumatoid factor and human gamma globulin.

Cellular reaction to complexes formed between rheumatoid factor and aggregated human gamma globulin.

During the course of experiments to investigate whether the addition of heat-denatured 7S y-globulin to rheumatoid leucocytes would produce transformation of the lymphocytes, an interesting phenomenon was observed. No specific stimulation of the lymphocytes was seen, but intracellular inclusions in neutrophils and macrophages, accompanied by extracellular bodies, were noted after culture of the...

Antinuclear factors in rheumatoid arthritis. Increasing organ-non-specificity with increasing reactivity of rheumatoid factor with heterologous gamma globulin.

McCormick and Day (1963) reported that rheumatoid factors and 7S ANF co-existing in the same seramayform high molecular weight complexes, and absorption studies have brought forward evidence of an interaction between ANF and rheumatoid factors when present in the same serum (Holborow and Johnson, 1965). However, ANF in rheumatoid arthritis have mostly been found in low frequency and chiefly in ...

the investigation of the relationship between type a and type b personalities and quality of translation

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